材料科学
金属有机骨架
三阴性乳腺癌
肿瘤微环境
纳米技术
微波食品加热
乳腺癌
纳米材料
癌症研究
生物医学工程
癌症
化学
肿瘤细胞
有机化学
医学
生物
计算机科学
吸附
电信
遗传学
作者
Qiong Wu,Ting Li,Zhen Jin,Xuxu Sun,Xiangling Ren,Changhui Fu,Lufeng Chen,Longfei Tan,Meng Niu,Xianwei Meng
标识
DOI:10.1021/acsami.2c13561
摘要
Hollow materials derived from metal–organic frameworks (MOFs) have emerged in the biomedical field due to their unique properties, and different synthesis methods have been proposed. However, so far, the large-scale use of hollow MOFs is mostly limited by the timeliness of synthesis methods. Herein, we propose a new ultrasonic aerosol flow strategy for the instantaneous synthesis of a Zr-MOF-derived hollow sphere complex (ZC-HSC) in only one step. Through rapid transient heating, the coordination between metal salts and organic ligands occurs along with prompt evaporation of the solvent. The whole process lasts for only about 21 s, compared with several steps that take hours or even days for conventional synthesis methods. Based on the ZC-HSC, we designed a nanodrug with the functions of manipulating the tumor microenvironment, which can reshape the tumor microenvironment by improving tumor hypoxia and inflammatory microenvironment and promoting antiangiogenic therapy. Combined with microwave thermo-chemotherapy, the nanodrugs effectively treat triple-negative breast cancer (the tumor cell survival rate was only 34.76 and 31.05% in normoxic and hypoxic states, respectively, and the tumor inhibition rate reached 87.9% at the animal level), providing a new theoretical basis for the treatment of triple-negative breast cancer. This rapid, one-step, and continuous ultrasonic aerosol flow strategy has bright prospects in the synthesis of MOF-derived hollow materials and promotes the further development of large-scale applications of biological nanomaterials.
科研通智能强力驱动
Strongly Powered by AbleSci AI