Beyond conventional adoptive T-cell therapy

hematopoietic stem and progenitor cells within 7 days. The cell product, called ProTcell, is composed mainly of cells expressing CD7, chemokine receptor proteins (eg, CCR9), and adhesion molecules (eg, L-selectin). After injection in NSG mice, ProTcell can differentiate and be educated in the thymus to generate simple positive T cells. Here, we summarize the current state of preclinical and clinical research using this approach, highlighting its potential advantages and current limitations for immune reconstitution therapies.