Selective Sensing of Lactate Dehydrogenase A by Naphthalene Diimide-Based AIEgen as a Diagnostic Probe toward Cancer Cells

. LDHA sensing by Al-Py FONPs was found to be highly selective against other biomolecules and enzymes. Al-Py FONPs were successfully utilized toward selective diagnosis of cancer cells (MDA-MB-231 and MCF-7) over normal cells (HEK 293) through quenching of their fluorescence by overexpressed LDHA within cancer cells. Therefore, Al-Py FONPs emerged as a diagnostic biomarker for selective and sensitive detection of LDHA by ministering their AIE property.