Enhancing Reaction Compatibility in Telescoped Multistep Flow Synthesis via Hybridizing Micro Packed-Bed/Micro Tubing Reactors: Application to Cyproflanilide and Broflanilide

(84% in 13.8 min) were achieved without intermediate isolation. Furthermore, the complete eight-step continuous synthesis of both insecticides, cyproflanilide and broflanilide, was also realized. Notably, this project leveraged dibenzo-18-crown-6 to modulate intrinsic kinetics and tailored flow configurations to intensify apparent kinetics, thus enabling a scalable, biphasic (water/oil) sulfinato-dehalogenation protocol, producing insecticide intermediates at the kilogram-per-day scale. This hybrid strategy demonstrates versatility in addressing reaction incompatibility during telescoped flow synthesis, advancing the practical implementation of continuous manufacturing.