Sirolimus Plus Low‐Exposure Calcineurin Inhibitors as an Alternative Graft‐Versus‐Host Disease Prophylaxis in Calcineurin Inhibitor‐Intolerant Recipients: A Retrospective Study

For allo-HSCT recipients with CNI intolerance, this study provides the first evaluation of sirolimus combined with low-exposure CNIs as a GvHD prophylaxis. Our findings suggest this regimen is a promising and feasible alternative, although validation in larger, prospective studies is warranted.