An ultrasmall PVP–Fe–Cu–Ni–S nano-agent for synergistic cancer therapy through triggering ferroptosis and autophagy

We have synthesized an ultrasmall Fe–Cu–Ni–S nano-agent with excellent photothermal conversion efficiency (∼96%), which can be applied for MRI-guided synergistic PTT/PDT/CDT of cancers through triggering ferroptosis and autophagy.