New diterpene lactone derivatives from Aphanamixis polystachya leaves inhibit nitric oxide production in RAW 264.7 cells

Five new acyclic diterpene lactone derivatives containing two rare structural fragments a γ / δ -lactone and a furan-3-one from Aphanamixis polystachya . They inhibited NO production in LPS activated RAW264.7 cells with IC 50 values of 16.8–37.7 μM.