Outcome of Brain Metastases Treated with Gamma Knife Stereotactic Radiosurgery: A Retrospective Cohort Study of 205 Cases

医学 放射外科 置信区间 回顾性队列研究 队列 外科 核医学 放射治疗 内科学
作者
Nourou Dine Adeniran Bankole,Adyl Melhaoui,Yasser Arkha,Semmar Afaf,Khalid Bouyakhlef,Mahjouba Boutarbouch,M. Jiddane,Abdeslam El Khamlichi
出处
期刊:World Neurosurgery [Elsevier BV]
卷期号:176: e462-e475
标识
DOI:10.1016/j.wneu.2023.05.083
摘要

Brain metastases (BMs) are the most common expansive intracranial lesions in adults. Approximately 50% of patients diagnosed with new BMs will have >1 BM at the diagnosis. We report our experience with BMs treated with Leksell Gamma Knife stereotactic radiosurgery (GKSR) and evaluate the outcomes. Patients treated by GKSR in our institution between 2008 and 2021 for BMs were evaluated retrospectively. A total of 205 patients (56.6% women) were included, with a median age of 59 years (range, 25–83 years). The breast (n = 85; 42.5%) and lung (n = 76; 38%) were the most common original locations for the primary tumors. Of the 205 patients, 103 (50.3%) had a single BM and 102 (49.7%) had ≥2 BMs. The median number of multiple BMs treated was 4 (range, 2–43). The mean overall survival (OS) time was 6.00 months (95% confidence interval [CI], 5.07–6.93 months) for all BMs. The median rate of tumor control after radiosurgery was 65% (range, 20%–99%) during a median follow-up of 6.00 months (95% CI, 3–84 months). In the overall population, the 1-, 2-, and 5-year OS rate was 37.55%, 25.12%, and 18.51%, respectively. The mean OS time was longer for those with multiple BMs than for those with a single BM (mean, 10 months [95% CI, 6.67–13.33 months] vs. mean, 5 months [95% CI, 4.21–5.70 months]; P = 0.03). Retreatment, tumor stability (control), and progression influenced the OS of patients with BMs, whether single or multiple (P < 0.001). GKSR provides good results in terms of OS and better quality of life for patients with BMs, whether single or multiple. Tumor stability and retreatment influenced the OS of patients with BMs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小橙完成签到 ,获得积分10
刚刚
科研小王完成签到,获得积分10
5秒前
小丫头发布了新的文献求助10
7秒前
科研小王发布了新的文献求助10
8秒前
梦梦完成签到,获得积分10
9秒前
guangshuang发布了新的文献求助10
10秒前
10秒前
amupf发布了新的文献求助10
11秒前
grasslands完成签到,获得积分10
11秒前
12秒前
一一完成签到 ,获得积分10
12秒前
13秒前
tjfwg完成签到,获得积分10
13秒前
CYT发布了新的文献求助10
14秒前
15秒前
NatureLee完成签到 ,获得积分10
15秒前
万能图书馆应助Yi采纳,获得10
16秒前
sduwl完成签到,获得积分10
16秒前
典雅雨寒完成签到,获得积分10
16秒前
18秒前
Mic发布了新的文献求助10
18秒前
grasslands发布了新的文献求助10
20秒前
勤恳的向日葵完成签到,获得积分10
20秒前
orixero应助blance采纳,获得10
20秒前
梦梦发布了新的文献求助10
20秒前
北冥有鱼完成签到 ,获得积分10
20秒前
26秒前
Xiaoxiao应助冷酷蛋挞采纳,获得10
27秒前
27秒前
强健的绮琴完成签到,获得积分10
27秒前
jacs111完成签到,获得积分10
27秒前
29秒前
零季发布了新的文献求助10
29秒前
Mic完成签到,获得积分10
31秒前
干净柏柳完成签到 ,获得积分10
31秒前
奥斯卡完成签到,获得积分0
32秒前
lijf2024发布了新的文献求助10
33秒前
PEI完成签到,获得积分10
33秒前
浮想圆影发布了新的文献求助10
33秒前
谷蓝完成签到,获得积分10
35秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Technologies supporting mass customization of apparel: A pilot project 450
Mixing the elements of mass customisation 360
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
the MD Anderson Surgical Oncology Manual, Seventh Edition 300
Nucleophilic substitution in azasydnone-modified dinitroanisoles 300
Political Ideologies Their Origins and Impact 13th Edition 260
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3781029
求助须知:如何正确求助?哪些是违规求助? 3326508
关于积分的说明 10227468
捐赠科研通 3041675
什么是DOI,文献DOI怎么找? 1669541
邀请新用户注册赠送积分活动 799100
科研通“疑难数据库(出版商)”最低求助积分说明 758734