Single-cell RNA sequencing analysis identified GARP-expressing myeloid cells that deteriorate postinfarct myocardial remodeling

Myeloid cells are known to contribute to the progression of myocardial infarction. However, the precise roles of these cells have not been fully elucidated. Single-cell RNA sequencing analysis demonstrated a population of glycoprotein A repetition-predominant (GARP)-expressing myeloid cells (GEM cells) that were derived from heart-resident fibrocytes. GEM cells were found to regulate neutrophil infiltration and cardiomyocyte apoptosis, resulting in detrimental cardiac remodeling. Spatial transcriptomics suggests that GEM cells are also present in human infarcted myocardium.