Tungstotellurate(VI)‐Based Nanocomposite Inhibits Breast Cancer Proliferation and Metastasis by Enhancing Cuproptosis and Apoptosis

) cluster exhibited potent antitumor effects via p53-dependent apoptotic pathway reactivation. In vitro studies demonstrated over 85.6% inhibition rate against 4T1 breast cancer cells when combining POM/Cu-SS@HA with 808 nm NIR irradiation. In vivo results showed 92.8% tumor growth suppression compared to the controls. Transcriptome analysis further identified altered expression profiles in glutathione (GSH) metabolism and mitochondrial function-related genes, confirming the dual induction of cuproptosis and apoptosis. These findings establish a synergistic nanotherapeutic strategy with enhanced efficacy for breast cancer treatment.