化学
神经科学
发病机制
荧光
不稳
病态的
纳米技术
机制(生物学)
帕金森病
心理学
病理
认识论
哲学
量子力学
疾病
物理
材料科学
医学
作者
Xiaoqian Sun,Qingqing Jiang,Yu Zhang,Jiali Su,Wenqu Liu,Juanjuan Lv,Fengtang Yang,Wei Shu
标识
DOI:10.1016/j.ejmech.2024.116195
摘要
Parkinson's disease (PD) is a common neurodegenerative disease. The clinical symptoms of PD are usually related to motor symptoms, including postural instability, rigidity, bradykinesia, and resting tremors. At present, the pathology of PD is not yet clear. Therefore, revealing the underlying pathological mechanism of PD is of great significance. A variety of bioactive molecules are produced during the onset of Parkinson's, and these bioactive molecules may be a key factor in the development of Parkinson's. The emerging fluorescence imaging technology has good sensitivity and high signal-to-noise ratio, making it possible to deeply understand the pathogenesis of PD through these bioactive molecules. Currently, fluorescent probes targeting PD biomarkers are widely developed and applied. This article categorizes and summarizes fluorescent probes based on different PD biomarkers, systematically introduces their applications in the pathological process of PD, and finally briefly elaborates on the challenges and prospects of these probes. We hope that this review will provide in-depth reference insights for designing fluorescent probes, and contribute to study of the pathogenesis and clinical treatment of PD.
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