亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Health-Related Quality of Life Profile and Symptom Burden of Patients with Aggressive B-Cell Lymphomas Just before CAR-T-Cell Therapy: A Real-World Study By the Gimema

医学 淋巴瘤 套细胞淋巴瘤 内科学 人口 生活质量(医疗保健) 肿瘤科 儿科 护理部 环境卫生
作者
Fabio Efficace,Pier Luigi Zinzani,Francesca Bonifazi,Michele Clerico,Annalisa Chiappella,Domenico Russo,Riccardo Saccardi,Barbara Botto,Thomas Baldi,Francesca Tartaglia,Enrico Orciuolo,Massimiliano Gambella,Maria Chiara Tisi,Maurizio Martelli,Claudio Cartoni,Martina Di Palma,Massimo Martino,Paolo Corradini,Paola Fazi,Marco Vignetti,Alice Di Rocco
出处
期刊:Blood [American Society of Hematology]
卷期号:142 (Supplement 1): 7384-7384
标识
DOI:10.1182/blood-2023-180012
摘要

Background Although efficacy and safety data on chimeric antigenic receptor (CAR) T-cell therapy for patients aggressive B-cell lymphomas are being accumulated, there is limited research on health-related quality of life (HRQoL) and symptom burden of these patients. Additionally, the few HRQoL data available mainly stems from selected patients enrolled in clinical trial settings. Objective The primary objective of this study was to compare HRQoL of patients with relapsed/refractory aggressive B-cell lymphomas just before receiving CAR T-cell infusion in real-life, with that of their peers in the general population. Secondary objectives were to describe the prevalence of disease-specific symptoms and worries, and to investigate the relationships between symptom burden and HRQoL and functional outcomes. Methods: Baseline data from an ongoing prospective observational study by the Italian GIMEMA Group were analyzed. Inclusion criteria were: adult patients with diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma, high grade B-cell lymphoma, and DLBCL transformed by indolent lymphoma and mantle cell lymphoma, scheduled to receive CAR T-cell therapy. HRQoL was assessed with the EORTC QLQ-C30 and its recently validated module for patients with high-grade non-Hodgkin lymphoma (EORTC QLQ-NHL-HG29). Multivariable linear regression analyses were performed to estimate the overall mean difference in the QLQ-C30 scores between patients and the general population, adjusting for age, sex and comorbidity. Evidence-based guidelines for interpretation of the QLQ-C30 were used to determine clinically meaningful differences between groups. The prevalence of patients who reported symptoms and worries on the QLQ-NHL-HG29 was based on the number of patients who answered, “a little,” “quite a bit,” or “very much” on a given item. This was assessed overall and by age groups. For descriptive purposes, we divided the sample by the median age, deriving two subgroups: younger (with a median age of 50 years; IQR: 41 - 56) and older patients (with a median age of 65 years; IQR: 63 - 71). Mean scores of functional and global QoL scales of the EORTC QLQ-C30 were analyzed by severity of symptom burden. Patients were categorized as having high or low symptom burden based on the median score of the validated symptom burden scale of the QLQ-NHL-HG29 questionnaire. Results Overall, 65 patients enrolled across 9 centers were analyzed. Median age at study entry was 61 years (IQR, 50-65) and 21 (32%) were women. Median time since diagnosis was 2 years (IQR, 1-4). Eighteen patients (28%) had already received autologous hematopoietic stem cell transplantation (auto-HSCT) before study inclusion. Median number of previous lines of therapy was 2 (IQR: 2-3), and eleven patients (18%) reported at least 1 comorbidity. Patients reported statistically and clinically meaningful worse scores across several domains, compared with their peers in the general population. The top three largest statistically and clinically meaningful differences with regard to functional scales were observed for role functioning (Δ=26.8, p<.001), social functioning (Δ=17.6, p<.001) and the global QoL scale (Δ=14.3, p<.001). With regard to symptoms, the two largest statistically and clinically meaningful worse symptoms, compared to the general population, were observed for fatigue (Δ=14.2, P<.001), dyspnea (Δ=10.9, p=.003) and financial difficulty (Δ=10.6, p=.001). Prevalence of symptoms and worries was high with more than 50% of patients reporting 14 different symptoms and worries. Younger patients tended to report a higher prevalence in regard to specific worries. The top ten most prevalent symptoms and worries by the QLQ-NHL-HG29, overall and by age groups, are reported in Table 1. Patients with a greater symptom burden had a clinically meaningful worse global QoL, and worse physical, role, social, and cognitive functioning compared to those with a lower symptom burden (Figure 1). Conclusion: Using a validated disease-specific measure for high-grade non-Hodgkin lymphoma, we observed that just before CAR T-cell therapy in real-life, patients report substantial HRQoL impairments and a high prevalence of symptoms and worries. Our findings also suggest to pay special attention to patients with a greater symptom burden, being a vulnerable group with important HRQoL and functional impairments.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
嗯嗯嗯完成签到 ,获得积分10
3秒前
托丽莲睡拿完成签到,获得积分10
14秒前
一口蛋黄酥完成签到 ,获得积分10
28秒前
Shandongdaxiu完成签到 ,获得积分10
34秒前
39秒前
Huang发布了新的文献求助10
46秒前
1分钟前
章访曼发布了新的文献求助10
1分钟前
章访曼完成签到,获得积分10
1分钟前
汉堡包应助科研通管家采纳,获得10
1分钟前
Akim应助immm采纳,获得10
1分钟前
winkyyang完成签到 ,获得积分10
1分钟前
August完成签到,获得积分10
1分钟前
惜寒完成签到 ,获得积分10
1分钟前
ala完成签到,获得积分10
1分钟前
2分钟前
淡定树叶完成签到 ,获得积分10
2分钟前
英俊的铭应助妩媚的以寒采纳,获得10
2分钟前
2分钟前
2分钟前
2分钟前
李博士发布了新的文献求助10
3分钟前
溟汐Seiuuu完成签到 ,获得积分10
3分钟前
messi发布了新的文献求助10
3分钟前
594778089完成签到,获得积分10
3分钟前
4分钟前
清爽幼枫发布了新的文献求助10
4分钟前
锖婧完成签到 ,获得积分10
4分钟前
OCDer完成签到,获得积分0
4分钟前
慕青应助鲸落采纳,获得10
4分钟前
4分钟前
鲸落发布了新的文献求助10
4分钟前
Orange应助胡强采纳,获得10
5分钟前
Magali应助科研通管家采纳,获得10
5分钟前
花陵完成签到 ,获得积分10
5分钟前
thousandsless完成签到 ,获得积分10
5分钟前
d.zhang完成签到,获得积分10
5分钟前
5分钟前
胡强发布了新的文献求助10
5分钟前
胡强完成签到,获得积分10
6分钟前
高分求助中
Un calendrier babylonien des travaux, des signes et des mois: Séries iqqur îpuš 1036
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
行動データの計算論モデリング 強化学習モデルを例として 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2545380
求助须知:如何正确求助?哪些是违规求助? 2175631
关于积分的说明 5600155
捐赠科研通 1896323
什么是DOI,文献DOI怎么找? 946218
版权声明 565334
科研通“疑难数据库(出版商)”最低求助积分说明 503552