重复性
材料科学
拉曼散射
表面等离子共振
荧光
生物分子
指纹(计算)
纳米技术
拉曼光谱
化学
光学
色谱法
纳米颗粒
计算机科学
物理
计算机安全
作者
Yibing Xie,Chao Chen,Chenguang Zhang,Li Xu,Zihou Li,Wenzhi Ren,Xiawei Xu,Yong Ren,Jie Lin,Aiguo Wu
出处
期刊:Nano Today
[Elsevier]
日期:2024-02-01
卷期号:54: 102140-102140
标识
DOI:10.1016/j.nantod.2023.102140
摘要
Conventional methodology for accurate identification of breast tumor subtypes is complex and time-consuming. Label-free SERS (surface-enhanced Raman scattering) enables rapid detection of biomolecules and provides intrinsic fingerprint information of analytes. Exploring reliable SERS bioprobes with high sensitivity and repeatability is essential for efficient typing of cancer cells. In this study, a novel core-shell noble metal-semiconductor Cu2O@Ag heterostructure with uniform morphology and outstanding SERS activity for label-free detection has been proposed. The Cu2O@Ag SERS substrates exhibit exceptional sensitivity to detect 4 nitrophenthiol (4NTP) at extreme low concentration (10−15 M), and the SERS spectra demonstrate excellent selectivity and repeatability (RSD ≈ 8.84%). The enhancement mechanism is attributed to the synergistic enhancement of photoinduced charge transfer and boosted surface plasmon resonance effect, confirmed by reduced fluorescence lifetime of methylene blue on SERS substrates and enhanced electromagnetic field intensity via finite-difference time-domain computational simulation. The ultrahigh sensitivity and good signal stability endow Cu2O@Ag SERS bioprobe potential for accurate detection of four breast cancer cells subtypes. The rich fingerprint information from SERS spectra is processed using linear differentiation analysis, revealing a high accuracy of 93.3% for subtypes classification. These results demonstrate an excellent SERS bioprobe with high sensitivity and repeatability for precision diagnosis has been developed.
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