神经病理性疼痛
神经科学
星形胶质细胞
中枢神经系统
医学
神经损伤
外周神经系统
神经系统
神经胶质
周围神经损伤
生物
坐骨神经
麻醉
作者
Aidan McGinnis,Ru-Rong Ji
出处
期刊:Cells
[MDPI AG]
日期:2023-03-22
卷期号:12 (6): 965-965
被引量:5
标识
DOI:10.3390/cells12060965
摘要
Preclinical studies have identified glial cells as pivotal players in the genesis and maintenance of neuropathic pain after nerve injury associated with diabetes, chemotherapy, major surgeries, and virus infections. Satellite glial cells (SGCs) in the dorsal root and trigeminal ganglia of the peripheral nervous system (PNS) and astrocytes in the central nervous system (CNS) express similar molecular markers and are protective under physiological conditions. They also serve similar functions in the genesis and maintenance of neuropathic pain, downregulating some of their homeostatic functions and driving pro-inflammatory neuro-glial interactions in the PNS and CNS, i.e., "gliopathy". However, the role of SGCs in neuropathic pain is not simply as "peripheral astrocytes". We delineate how these peripheral and central glia participate in neuropathic pain by producing different mediators, engaging different parts of neurons, and becoming active at different stages following nerve injury. Finally, we highlight the recent findings that SGCs are enriched with proteins related to fatty acid metabolism and signaling such as Apo-E, FABP7, and LPAR1. Targeting SGCs and astrocytes may lead to novel therapeutics for the treatment of neuropathic pain.
科研通智能强力驱动
Strongly Powered by AbleSci AI