喹诺酮类
药效团
药品
抗生素
抗药性
抗菌剂
计算生物学
药理学
生物
微生物学
生物信息学
作者
Wang Jun,Yu-min Shi,Hao Yan
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2023-03-01
卷期号:15 (6): 555-578
被引量:2
标识
DOI:10.4155/fmc-2023-0002
摘要
Quinolone derivatives, represented by fluoroquinolones, have emerged as the most commonly prescribed antibacterials for the treatment of various bacterial infections. In particular, the combination of a quinolone moiety with other antibacterial pharmacophores has the potential to act on different drug targets, which in turn, overcome drug resistance. Accordingly, quinolone hybrids are useful prototypes for fighting drug-resistant pathogens. The purpose of the present review is to provide an emphasis on the current scenario of quinolone hybrids with potential antibacterial activity against drug-resistant pathogens, covering articles published in the past 10 years. The structure-activity relationships, various aspects of rational design and mechanisms of action are also discussed to facilitate further rational development of more effective candidates.
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