粳稻
化学
糖苷
立体化学
抗氧化剂
二维核磁共振波谱
MTT法
传统医学
植物
细胞生长
有机化学
生物化学
生物
医学
作者
Jinqian Yu,Kai Wang,Hengqiang Zhao,Long Chen,Xiao Wang
出处
期刊:Fitoterapia
[Elsevier]
日期:2022-10-01
卷期号:162: 105277-105277
被引量:1
标识
DOI:10.1016/j.fitote.2022.105277
摘要
Six new isolates including three new alkaloids (1-3), one new secoiridoid glycoside (4) and one new 11-delactonization-secoiridoid glycoside (5), and one new organic acid (6) were identified from the leaves of Lonicera japonica, among which 1 and 2 assigned as a pair of configurational isomers possessed two oxazolidin-2-one fragments connected through NN bond. The structures were elucidated by the NMR data and ICD analysis. All the compounds (1-6) were tested for their antioxidant and hepatoprotective activities using cell models of ABAP-induced HepG2 cell and APAP-induced HepG2 cell by the MTT method. Outstandingly, compound 2 exhibited remarkable antioxidative activity with inhibitory rate of 117.2%, and compounds 2, 4, 6 exhibited significant effects with inhibitory rates of 68.1%, 69.3%, 69.2%, respectively.
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