神经退行性变
过渡(遗传学)
大脑活动与冥想
功能近红外光谱
神经科学
疾病
医学
心理学
脑电图
认知
内科学
生物
生物化学
基因
前额叶皮质
作者
Jiewei Lu,Yue Wang,Zhilin Shu,Mengjie Zhang,Jin Wang,Yuanyuan Cheng,Zhizhong Zhu,Yang Yu,Jialing Wu,Jianda Han,Ningbo Yu
标识
DOI:10.1088/1741-2552/ac861e
摘要
Abstract Objective. Parkinson’s disease (PD) is a common neurodegenerative brain disorder, and early diagnosis is of vital importance for treatment. Existing methods are mainly focused on behavior examination, while the functional neurodegeneration after PD has not been well explored. This paper aims to investigate the brain functional variation of PD patients in comparison with healthy controls. Approach. In this work, we propose brain hemodynamic states and state transition features to signify functional degeneration after PD. Firstly, a functional near-infrared spectroscopy (fNIRS)-based experimental paradigm was designed to capture brain activation during dual-task walking from PD patients and healthy controls. Then, three brain states, named expansion, contraction, and intermediate states, were defined with respect to the oxyhemoglobin and deoxyhemoglobin responses. After that, two features were designed from a constructed transition factor and concurrent variations of oxy- and deoxy-hemoglobin over time, to quantify the transitions of brain states. Further, a support vector machine classifier was trained with the proposed features to distinguish PD patients and healthy controls. Main results. Experimental results showed that our method with the proposed brain state transition features achieved classification accuracy of 0.8200 and F score of 0.9091, and outperformed existing fNIRS-based methods. Compared with healthy controls, PD patients had significantly smaller transition acceleration and transition angle. Significance. The proposed brain state transition features well signify functional degeneration of PD patients and may serve as promising functional biomarkers for PD diagnosis.
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