Lactococcus lactis HkyuLL 10 suppresses colorectal tumourigenesis and restores gut microbiota through its generated alpha-mannosidase

OBJECTIVE: in colorectal cancer (CRC). DESIGN: -CM) and functional protein was studied in human CRC cells, patient-derived organoids and xenograft mice. RESULTS: -secreted proteins, and we identified that α-mannosidase was the functional protein. The antitumourigenic effect of α-mannosidase was demonstrated in human CRC cells and organoids, and its supplementation significantly reduced tumour growth in xenograft mice. CONCLUSION: administration may serve as a prophylactic measure against CRC.