免疫原性
病毒学
H5N1亚型流感病毒
病毒释放
生物
接种疫苗
血凝素(流感)
新城疫
抗体
免疫系统
体液免疫
病毒
免疫
免疫学
微生物学
作者
F Ingrao,Eva Ngabirano,Fabienne Rauw,Gwenae͏̈lle Dauphin,Bénédicte Lambrecht
出处
期刊:Vaccine
[Elsevier]
日期:2024-04-01
标识
DOI:10.1016/j.vaccine.2024.04.038
摘要
The application of recombinant herpesvirus of turkey, expressing the H9 hemagglutinin gene from low pathogenic avian influenza virus (LPAIV) H9N2 and the avian orthoavulavirus-1 (AOAV-1) (commonly known as Newcastle Disease virus (NDV)) fusion protein (F) as an rHVT-H9-F vaccine, is an alternative to currently used classical vaccines. This study investigated H9- and ND-specific humoral and mucosal responses, H9-specific cell-mediated immunity, and protection conferred by the rHVT-H9-F vaccine in specific pathogen-free (SPF) chickens. Vaccination elicited systemic NDV F- and AIV H9-specific antibody response but also local antibodies in eye wash fluid and oropharyngeal swabs. The ex vivo H9-specific stimulation of splenic and pulmonary T cells in the vaccinated group demonstrated the ability of vaccination to induce systemic and local cellular responses. The clinical protection against a challenge using a LPAIV H9N2 strain of the G1 lineage isolated in Morocco in 2016 was associated with a shorter duration of shedding along with reduced viral genome load in the upper respiratory tract and reduced cloacal shedding compared to unvaccinated controls.
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