自噬
二甲双胍
ULK1
渗透(HVAC)
医学
PI3K/AKT/mTOR通路
肩袖
脂联素
内科学
内分泌学
安普克
癌症研究
生物
外科
激酶
胰岛素
胰岛素抵抗
细胞生物学
信号转导
蛋白激酶A
细胞凋亡
生物化学
物理
热力学
作者
Hao Zhang,Xingzuan Lin,Shiping Feng,Siyuan Zhu,Han Zhou,Huifang Chen,Yang He,Zhiyue Wang,Ru Wang,Xiexiang Shao,Jianhua Wang
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2024-04-08
标识
DOI:10.1152/ajpcell.00034.2024
摘要
Muscular fatty infiltration is a common issue after rotator cuff tears (RCT) which impairs shoulder function. Females suffer higher prevalence and more severe degree of muscular fatty infiltration after RCT when compared to males, with the underlying mechanisms remaining unclear. Fibro/adipogenic progenitors (FAPs) are the primary source of muscular fatty infiltration following RCT. Our findings disclose that gender-specific disparities in muscular fatty infiltration are linked to mTOR/ULK1-mediated autophagy of FAPs. Decreased autophagic activity contributes to adipogenic differentiation in female FAPs after RCT. Furthermore, metformin could enhance mTOR/ULK1 mediated autophagic processes of FAPs, thereby alleviating fatty infiltration and improving shoulder functionality after RCT. Together, our study reveals that gender differences in muscular fatty infiltration arise from distinct autophagic activities. Metformin could be a promising non-invasive intervention to ameliorate muscular fatty infiltration of RCT.
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