Commentary on the Article titled “Altered in vivo early neurogenesis traits in patients with depression: Evidence from neuron-derived extracellular vesicles and electroconvulsive therapy” by Xie et al.

One of the hottest themes in neurobiology now is small extracellular vesicles (sEVs), particularly their involvement in diagnostics [1]. One distinctive advantage of sEVs usage in this context is permeability of blood-brain barrier to the vesicles [2]. Neuronal sEVs entering the bloodstream can give some evidence of neurodegenerative disease, for example, Alzheimer's [3] well before clinical manifestations. Moreover, content of patients' neuron-derived sEVs may suggest mechanisms of psychiatric diseases [4].