高强度
白质
病理
病态的
闭塞
医学
冲程(发动机)
内科学
心脏病学
内分泌学
磁共振成像
放射科
机械工程
工程类
作者
Jing Lin,Linfang Lan,Dilong Wang,Baoshan Qiu,Yuhua Fan
出处
期刊:Neuroscience
[Elsevier]
日期:2017-12-01
卷期号:367: 72-84
被引量:14
标识
DOI:10.1016/j.neuroscience.2017.10.031
摘要
To mimic the expected pathological changes of white matter lesions (WMLs) and increase the stability, we applied modified two-vessel occlusion (modified 2VO) (1-week interval bilateral carotid artery occlusion) in stroke-prone renovascular hypertensive rats (RHRSP) and established a modified WMLs model (RHRSP/modified 2VO) that compared their phenotypes with RHRSP and sham-operated rats. In addition, we tried to differentiate small veins from small arteries through the presence of smooth muscle to study the pathological changes of small veins detailed in the model. RHRSP/modified 2VO rats showed higher stability and more extensive white matter damage without an obvious increase in mortality rate at 12 weeks after the modified 2VO operation compared to RHRSP rats. RHRSP/modified 2VO rats showed more severe small venous collagen deposition than RHRSP rats, and the majority of the deposition was collagen I and IV rather than collagen III. In addition, RHRSP/modified 2VO rats possessed cognitive impairment, mild wall thickness and blood-brain barrier disruption. Our findings suggest that the modified WMLs model (RHRSP/modified 2VO) mimics cognitive impairment and small vessel pathological changes similar to WMLs in humans. Differentiating small veins from small arteries through smooth muscle is feasible, and marked small venous deposition may play an important role in the hypertensive white matter lesions.
科研通智能强力驱动
Strongly Powered by AbleSci AI