IκB激酶
NF-κB
信号转导
细胞生物学
激酶
NFKB1型
核蛋白
基因
αBκ
生物
神经炎症
核出口信号
神经退行性变
蛋白激酶A
转录因子
胞浆
医学
炎症
肌萎缩侧索硬化
核心
神经科学
神经保护
肿瘤坏死因子α
遗传学
细胞核
生物化学
酶
作者
Shareen Singh,Thakur Raghu Raj Singh
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2020-01-01
卷期号:18 (10): 918-935
被引量:67
标识
DOI:10.2174/1570159x18666200207120949
摘要
A transcriptional regulatory nuclear factor kappa B (NF-κB) protein is a modulator of cellular biological activity via binding to a promoter region in the nucleus and transcribing various protein genes. The recent research implicated the intensive role of nuclear factor kappa B (NF-κB) in diseases like autoimmune disorder, inflammatory, cardiovascular and neurodegenerative diseases. Therefore, targeting the nuclear factor kappa B (NF-κB) protein offers a new opportunity as a therapeutic approach. Activation of IκB kinase/NF-κB signaling pathway leads to the development of various pathological conditions in human beings, such as neurodegenerative, inflammatory disorders, autoimmune diseases, and cancer. Therefore, the transcriptional activity of IκB kinase/NF- κB is strongly regulated at various cascade pathways. The nuclear factor NF-kB pathway plays a major role in the expression of pro-inflammatory genes, including cytokines, chemokines, and adhesion molecules. In response to the diverse stimuli, the cytosolic sequestered NF-κB in an inactivated form by binding with an inhibitor molecule protein (IkB) gets phosphorylated and translocated into the nucleus further transcribing various genes necessary for modifying various cellular functions. The various researches confirmed the role of different family member proteins of NF-κB implicated in expressing various genes products and mediating various cellular cascades. MicroRNAs, as regulators of NF- κB microRNAs play important roles in the regulation of the inflammatory process. Therefore, the inhibitor of NF-κB and its family members plays a novel therapeutic target in preventing various diseases. Regulation of NF- κB signaling pathway may be a safe and effective treatment strategy for various disorders.
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