蒿甲醚
安普克
PI3K/AKT/mTOR通路
糖尿病
糖原
信号转导
脂质代谢
蛋白激酶B
内分泌学
药理学
内科学
医学
生物
酶
蛋白激酶A
细胞生物学
生物化学
青蒿素
免疫学
疟疾
恶性疟原虫
作者
Xiaolin Bai,Ruixia Pei,Wen Lei,Meiyun Zhao,Jialin Zhang,Lü Tian,Junke Shang
标识
DOI:10.3389/fendo.2020.568864
摘要
The traditional Chinese medicine has long been used in the treatment of diabetes, one major disease threatening the public health. It has been reported that artemether exerts antidiabetic effects on type 2 diabetes in db/db mice, however the underlying mechanisms remain unknown. In the present study, we show that artemether regulates expression of related enzymes participating in the glucose and lipid metabolism in the liver of db/db mice, which could at least partly explain the improved glucose and lipid metabolism in artemether-treated mice. Additionally, artemether also regulates expression of glycogen synthesis related enzymes in the skeletal muscle of db/db mice, supporting its promotive role in glycogen synthesis. Mechanistically, artemether activates AMPK pathway as well as PI3K/Akt pathway in the liver and skeletal muscle of db/db mice, suggesting that these two signaling pathways are both involved in the antidiabetic effects of artemether on type 2 diabetes in db/db mice. In conclusion, our study connects the antidiabetic effects of artemether to the regulation of metabolic enzymes and signaling pathways, and also provides molecular basis for the potential application of artemether in treating type 2 diabetes.
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