声动力疗法
材料科学
活性氧
肿瘤缺氧
纳米技术
医学
放射治疗
化学
生物化学
内科学
作者
Shuang Liang,Xiaoran Deng,Guangyao Xu,Xiao Xiao,Meifang Wang,Xiasheng Guo,Ping’an Ma,Ziyong Cheng,Dong Zhang,Jun Lin
标识
DOI:10.1002/adfm.201908598
摘要
Abstract Sonodynamic therapy (SDT) activated by ultrasound is attractive as a potential alternative to conventional phototriggered therapies owing to the deeper penetration depth and the absence of phototoxicity. Nevertheless, the low quantum yield of nano‐sonosensitizer and the tumor hypoxia remain significant challenges for SDT. Herein, a novel TiO 2 ‐based nano‐sonosensitizer is reported to bilaterally enhance the quantum yield by simultaneous integration of precious metal Pt nanoparticles (NPs) and an oxygen‐deficient layer. Furthermore, the hollow cavity of TiO 2 serves as a reservoir to load doxorubicin, an anticancer drug for chemotherapy as well as a molecular sonosensitizer for SDT. The decorated Pt NPs act as nanozymes to catalyze the decomposition of endogenous hydrogen peroxide for the generation of oxygen to alleviate tumor hypoxia, reduce resistance to chemotherapy, and provide sufficient oxygen source for subsequently facilitating SDT‐induced reactive oxygen species production. The high chemo‐sonodynamic synergistic efficacy is systematically demonstrated both in vitro and in vivo. More importantly, it is believed that the novel design and the new finding in the synthesis of Pt–TiO 2 heterostructures can be popularized for the preparation and application of the semiconductor‐based nanoplatforms in many fields.
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