免疫系统
免疫学
生物
机制(生物学)
免疫病理学
抗逆转录病毒疗法
人类免疫缺陷病毒(HIV)
免疫功能障碍
病毒学
病毒载量
认识论
哲学
作者
Xiaodong Yang,Bin Su,Xin Zhang,Yan Liu,Hao Wu,Tong Zhang
标识
DOI:10.1002/jlb.4mr1019-189r
摘要
Abstract The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically diminished by the grounds of the introduction of potent antiretroviral therapy, which induces persistent suppression of HIV-1 replication and gradual recovery of CD4+ T-cell counts. However, ∼10–40% of HIV-1-infected individuals fail to achieve normalization of CD4+ T-cell counts despite persistent virological suppression. These patients are referred to as “inadequate immunological responders,” “immunodiscordant responders,” or “immunological non-responders (INRs)” who show severe immunological dysfunction. Indeed, INRs are at an increased risk of clinical progression to AIDS and non-AIDS events and present higher rates of mortality than HIV-1-infected individuals with adequate immune reconstitution. To date, the underlying mechanism of incomplete immune reconstitution in HIV-1-infected patients has not been fully elucidated. In light of this limitation, it is of substantial practical significance to deeply understand the mechanism of immune reconstitution and design effective individualized treatment strategies. Therefore, in this review, we aim to highlight the mechanism and risk factors of incomplete immune reconstitution and strategies to intervene.
科研通智能强力驱动
Strongly Powered by AbleSci AI