生物
间质细胞
细胞生物学
骨髓
造血
干细胞
间充质干细胞
重编程
再生(生物学)
内皮干细胞
癌症研究
免疫学
细胞
遗传学
体外
作者
Keane Jared Guillaume Kenswil,Paola Pisterzi,Gonzalo Sánchez‐Duffhues,Claire van Dijk,Andrea Lolli,Callie Knuth,Byambasuren Vanchin,Adrian Christopher Jaramillo,Remco M. Hoogenboezem,Mathijs A. Sanders,Jacqueline Feyen,Tom Cupedo,Ivan G. Costa,Ronghui Li,Eric Bindels,Kirsten Lodder,Bianca Blom,P.K. Bos,Marie‐José Goumans,Peter ten Dijke,Eric Farrell,Guido Krenning,Marc H.G.P. Raaijmakers
出处
期刊:Cell Stem Cell
[Elsevier]
日期:2021-04-01
卷期号:28 (4): 653-670.e11
被引量:29
标识
DOI:10.1016/j.stem.2021.01.006
摘要
Bone marrow stromal cells (BMSCs) play pivotal roles in tissue maintenance and regeneration. Their origins, however, remain incompletely understood. Here we identify rare LNGFR+ cells in human fetal and regenerative bone marrow that co-express endothelial and stromal markers. This endothelial subpopulation displays transcriptional reprogramming consistent with endothelial-to-mesenchymal transition (EndoMT) and can generate multipotent stromal cells that reconstitute the bone marrow (BM) niche upon transplantation. Single-cell transcriptomics and lineage tracing in mice confirm robust and sustained contributions of EndoMT to bone precursor and hematopoietic niche pools. Interleukin-33 (IL-33) is overexpressed in subsets of EndoMT cells and drives this conversion process through ST2 receptor signaling. These data reveal generation of tissue-forming BMSCs from mouse and human endothelial cells and may be instructive for approaches to human tissue regeneration.
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