旁分泌信号
成纤维细胞生长因子
自分泌信号
成纤维细胞生长因子受体
受体酪氨酸激酶
前列腺
内海
癌症研究
医学
内分泌学
细胞生物学
内科学
信号转导
癌症
生物
受体
血管生成
前列腺癌
遗传学
作者
Arianna Giacomini,Elisabetta Grillo,Sara Rezzola,Doménico Ribatti,Marco Rusnati,Roberto Ronca,Marco Presta
标识
DOI:10.1152/physrev.00005.2020
摘要
Fibroblast growth factors (FGFs) are a family of proteins possessing paracrine, autocrine, or endocrine functions in a variety of biological processes, including embryonic development, angiogenesis, tissue homeostasis, wound repair, and cancer. Canonical FGFs bind and activate tyrosine kinase FGF receptors (FGFRs), triggering intracellular signaling cascades that mediate their biological activity. Experimental evidence indicates that FGFs play a complex role in the physiopathology of the prostate gland that ranges from essential functions during embryonic development to modulation of neoplastic transformation. The use of ligand- and receptor-deleted mouse models has highlighted the requirement for FGF signaling in the normal development of the prostate gland. In adult prostate, the maintenance of a functional FGF/FGFR signaling axis is critical for organ homeostasis and function, as its disruption leads to prostate hyperplasia and may contribute to cancer progression and metastatic dissemination. Dissection of the molecular landscape modulated by the FGF family will facilitate ongoing translational efforts directed toward prostate cancer therapy.
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