Efficacy of autologous platelet rich plasma gel in soft and hard tissue healing after surgical extraction of impacted mandibular third molar - A prospective study

Abstract Objectives This prospective study was designed to assess the efficacy of autologous PRP gel in healing of extraction socket after surgical extraction of impacted mandibular third molar. Methods A total of 100 patients necessitating treatment were randomly allocated in two groups; experimental and control. In experimental group, PRP gel was placed in the extraction socket after extraction, whereas in control group the similar procedure was carried out without application of PRP gel. The outcome variables were pain, swelling, and maximum mouth opening, which were assessed on 1st, 3rd, 5th, 7th and 14th day following extraction. Socket healing was analyzed radiographically by allocating scores for overall density and trabecular pattern on 4th, 10th and 16th week postoperatively. Results Results showed significant lower pain scores, reduced facial swelling and improved interincisal opening in experimental group postoperatively when compared to control group. The bone density and trabeculae pattern in both groups didnot show any difference at 4th week. However, highly significant difference (P value Conclusions The present study concludes that the use of simple, cost- effective method of autologous PRP gel may be beneficial to enhance the wound healing process and promotes bone regeneration.