PRDM16
脂肪组织
产热
转录因子
白色脂肪组织
Wnt信号通路
褐色脂肪组织
内分泌学
内科学
产热素
脂肪细胞
脂肪生成
生物
FGF21型
细胞生物学
医学
肥胖
脂肪因子
胰岛素抵抗
基因
信号转导
遗传学
作者
Hai P. Nguyen,Danielle Yi,Hei Sook Sul
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2020-01-01
卷期号:: 521-534
被引量:1
标识
DOI:10.1016/b978-0-12-819404-1.00025-7
摘要
White adipose tissue (WAT) is the primary energy storage organ and its excess contributes to obesity, while brown adipose tissue (BAT) and inducible thermogenic (beige/brite) adipocytes in WAT dissipate energy via UCP1 to maintain body temperature. Adipose tissues can develop during embryogenesis and after birth depending on anatomical origin. In adipose tissue, differentiation of adipose precursors to adipocytes is governed by transcription factors such as PPARγ, C/EBPβ, Zfp423, and Sox9 and this process is tightly regulated by secreted factors including Pref-1 and Wnt. Additionally, thermogenic gene activation in brown and beige adipocytes relies on common transcriptional machinery that includes PRDM16, Zfp516, Zc3h10, and LSD1, play an important role in regulating the thermogenic gene program. These transcription factors actions are also regulated by metabolites that acts as agonists or cofactor. With the presence of BAT-like tissues in human adults, increasing thermogenic activity these tissues may help to combat obesity.
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