Overproduction of Moniliphenone, a Benzophenone Biosynthetic Intermediate of Chloromonilicin, byMonilinia fructicolaand Its Anthraquinone Precursors

The accumulation of moniliphenone (3), a benzophenone biosynthetic intermediate of an antibiotic chloromonilicin (1), by M. fructicola was enhanced 15–16 times with the presence of bromine ions in the medium. Two anthraquinone pigments, chrysophanol (4) and emodin (5), also isolated from the mycelia, were proved to be precursors of 3 by incorporation experiments of the deuterium derivatives of these pigments into 3.