中缝背核
5-羟色胺能
神经营养因子
内分泌学
脑源性神经营养因子
内科学
糖尿病
抗焦虑药
TPH2型
抗抑郁药
心理学
医学
神经科学
作者
Jianbo Xiu,Rongrong Han,Zeyue Liu,Jiayu Li,Shu Liu,Yan Shen,Yu-Qiang Ding,Qi Xu
标识
DOI:10.2337/figshare.14531346
摘要
Moods and metabolism modulate each other. High comorbidity of depression and metabolic disorders such as diabetes and obesity poses a great challenge to treat such condition. Here we report the therapeutic efficacy of brain-derived neurotrophic factor (BDNF) by gene transfer in the dorsal raphe nucleus (DRN) in a chronic unpredictable mild stress model of depression (CUMS) and models of diabetes and obesity. In CUMS, BDNF-expressing mice displayed antidepressant- and anxiolytic-like behaviors, which are associated with augmented serotonergic activity. Both in the diet-induced obesity model (DIO) and in <i>db/db</i> mice,BDNF ameliorated obesity and diabetes, which may be mediated by enhanced sympathetic activity, not involving DRN serotonin. Chronic activation of DRN neurons via chemogenetic tools produced similar effects as BDNF in DIO mice. These results established the DRN as a key nexus in regulating depression-like behaviors and metabolism, which can be exploited to combat comorbid depression and metabolic disorders via BDNF gene transfer.
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