加氧酶
羟基化
双加氧酶
化学
膨胀的
酶
催化作用
生化工程
功能(生物学)
生物化学
材料科学
抗压强度
工程类
复合材料
作者
Jennifer Bridwell-Rabb,Jianxin Liu,Jiayi Tian,Zerick Dill
标识
DOI:10.1096/fasebj.2022.36.s1.0i122
摘要
Rieske Oxygenases are enzymes that showcase the remarkable ability to functionalize an inert C-H bond. These enzymes use a Rieske [2Fe-2S] cluster and a mononuclear iron center to bind and activate molecular oxygen. Using these metallocenters, Rieske Oxygenases have been shown to catalyze a variety of reactions, including one, two, and sequential hydroxylation reactions. This chemistry is important to the biosynthetic pathways of multiple organisms and is thus attractive for industrially building and tailoring natural product scaffolds. Similarly, the chemistry of the Rieske Oxygenases is abundant in degradative pathways and therefore offers compelling strategies for degrading environmental pollutants. However, a traditional lack of structure-function information for this expansive class of enzymes has restricted our ability to capitalize on these important and diverse catalytic strategies. Therefore, our laboratory is working to understand the architectural features of these enzymes that allow them to control and facilitate catalysis. Here, we present our current understanding of how these enzymes selectively catalyze reactions and use structure to guide chemical outcome.
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