膜
生物相容性
普鲁兰
伤口愈合
极限抗拉强度
生物高聚物
化学
生物医学工程
材料科学
透氧性
肉芽组织
化学工程
外科
复合材料
氧气
有机化学
生物化学
医学
多糖
聚合物
工程类
作者
Touba Khaliq,Muhammad Sohail,Syed Ahmed Shah,Arshad Mahmood,Mubeen Kousar,Nazish Jabeen
标识
DOI:10.1016/j.ijbiomac.2022.04.156
摘要
Hydrogel membrane dressings with multifunctional tunable properties encompassing biocompatibility, anti-bacterial, oxygen permeability, and adequate mechanical strength are highly preferred for wound healing. The present study aimed to develop biopolymer-based hydrogel membranes for the controlled release of therapeutic agent at the wound site. Toward this end we developed Cefotaxime sodium (CTX) loaded keratin (KR)-pullulan (PL) based hydrogel membrane dressings. All membranes show optimized vapor transmission rate (≥1000 g/ m2/day), oxygen permeability >8.2 mg/mL, MTT confirmed good biocompatibility and sufficient tensile strength (17.53 ± 1.9) for being used as a wound dressing. Nonetheless, KR-PL-PVA membranes show controlled CTX release due to enriched hydrophilic moieties which protect the wound from getting infected. In vivo results depict that CTX-KR-PL-PVA membrane group shows a rapid wound closure rate (p < 0.05) with appreciable angiogenesis, accelerated re-epithelization, and excessive collagen deposition at the wound site. These results endorsed that CTX-KR-PL-PVA hydrogel membranes are potential candidates for being used as dressing material in the diabetic wound.
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