光动力疗法
体内
口腔粘膜
聚丙烯酸
材料科学
癌症研究
医学
病理
生物
化学
生物技术
复合材料
有机化学
聚合物
作者
Xing Wang,Zuoying Yuan,Anqi Tao,Pudi Wang,Wenyue Xie,Shuo Yang,Jianyong Huang,Ning Wen
出处
期刊:Biomaterials
[Elsevier]
日期:2022-02-01
卷期号:281: 121377-121377
被引量:21
标识
DOI:10.1016/j.biomaterials.2022.121377
摘要
Oral potentially malignant disorders (OPMDs) are precursor lesions with an increased risk of malignant transformation. Topical photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (ALA) (ALA-PDT) is a promising therapeutic method in the treatment of OPMDs. However, the clinical application of topical ALA-PDT is restricted by several limitations, including low delivery efficiency, poor comfort, and easy influence by saliva. Here, we designed a highly adhesion-strength dry polyacrylic acid (PAA)-chitosan (CHI)-ALA interpenetrating network hydrogel (PACA) patch after investigating the spatiotemporal dynamics of ALA drug delivery via diffusion-based finite-element models. The PACA patch could adhere to the moist oral mucosa fast and stably and deliver ALA. PACA hydrogel-mediated PDT (PACA-PDT) effectively improved OPMDs in vitro and in a hamster oral carcinogenesis model. In particular, we conducted a trial to recruit 60 OPMD volunteers to demonstrate the feasibility and comfort of the PACA hydrogel patch. This study provides evidence that PACA hydrogel-mediated PDT could be a patient-friendly treatment modality for OPMDs.
科研通智能强力驱动
Strongly Powered by AbleSci AI