毛细管电色谱
纳米颗粒
电色谱法
胶体金
半胱氨酸
化学
毛细管电泳
固定相
色谱法
相(物质)
组合化学
材料科学
纳米技术
有机化学
酶
作者
Pandeng Miao,Ying Xi,Zijie Feng,Jian Zhang,Yingxiang Du,Cheng Chen
出处
期刊:Analytical Methods
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:14 (20): 1982-1987
摘要
Nanoparticles, which have unique properties, have attracted growing attention in enantiomeric separation nowadays. In this paper, an L-cysteine functionalized gold nanoparticle (L-Cys-GNP) based capillary column was prepared and applied in separating drug enantiomers in capillary electrochromatography (CEC) with lactobionic acid (LA) as a chiral selector. Compared with bare fused-silica capillary columns, the capillary columns modified with L-Cys-GNPs showed excellent chiral separation performance. A series of parameters affecting the enantiomeric separation were systematically investigated.
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