结合
光热治疗
化学
透明质酸
壳聚糖
组合化学
阿霉素
酰肼
纳米棒
光热效应
生物物理学
材料科学
化疗
纳米技术
生物化学
有机化学
生物
数学分析
遗传学
数学
作者
Guangdong Hou,Junmin Qian,Weiqing Xu,Tao Sun,Yaping Wang,Jinlei Wang,Lijie Ji,Aili Suo
标识
DOI:10.1016/j.carbpol.2019.02.045
摘要
Chemo-photothermal combination therapy is a promising strategy for cancer treatment. In this study, to achieve the combined photothermal-chemotherapy of breast cancer, a pH-sensitive oxidized hyaluronic acid-decorated dihydroxyphenyl/hydrazide bifunctionalized hydroxyethyl chitosan (DHHC)-gold nanorod (GNR) conjugate was developed. DHHC was synthesized by successive dihydroxyphenylation and hydrazidation of hydroxyethyl chitosan through carbodiimide reaction and click chemistry, respectively. The conjugate was obtained by chemically bonding DHHC onto GNR via Au-catechol bonds. Doxorubicin (DOX) was loaded onto the conjugate via an acid-labile hydrazone linkage with a drug loading content of 5.1%. DOX-loaded conjugate displayed good stability in neutral aqueous solutions and exhibited pH-responsive drug release and surface charge reversal behaviors. In vitro biological studies indicated that the conjugate could be effectively internalized by breast cancer MCF-7 cells and synergistic therapeutic effects were demonstrated, suggesting its great potential in combined photothermal-chemotherapy of breast cancer.
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