保健品
胰岛素抵抗
2型糖尿病
肠道菌群
2型糖尿病
碳水化合物代谢
胰岛素
疾病
糖尿病
医学
肥胖
生物
生物信息学
药理学
内分泌学
内科学
生物化学
免疫学
作者
Chao Zhao,Chengfeng Yang,Sydney Tang Chi Wai,Yanbo Zhang,María P. Portillo,Paolo De Paoli,Yijing Wu,Wai San Cheang,Bin Liu,Christian Carpéné,Satyajit D. Sarker,Hui Cao
标识
DOI:10.1080/10408398.2018.1501658
摘要
Type 2 diabetes mellitus (T2DM) is the most prevalent disease and becoming a serious public health threat worldwide. It is a severe endocrine metabolic disorder that has the ability to induce serious complications in all kinds of organs. Although mechanisms of anti-diabetics have been described before, we focus here on the cellular and physiological mechanisms involved in the modulation of insulin and glucose blood levels. As obesity and inflammation are intimately associated with the development of T2DM, their possible relationships are also described. The effects of gut microbiota on insulin resistance have been recently investigated in clinical trials, and we discuss the potential mechanisms by which gut microbiota may improve glucose handling, especially via the metabolism of ingested phytochemicals. Among the historically supported effects of phytochemicals, their therapeutic potential for T2DM leads to consider these natural products as an important pool for the identification of novel anti-diabetic drug leads. This current research extends the descriptions of anti-diabetic effects of plants that are used in traditional medicines or as nutraceuticals. The objective of the present review is to make a systematic report on glucose metabolism in T2DM as well as to explore the relationships between natural phytochemicals and glucose handling.
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