Evaluation of POLE and POLD1 Mutations as Biomarkers for Immunotherapy Outcomes Across Multiple Cancer Types

Discussion | Our findings extend prior research in other settings he primary limitations of this study are that the data were self-reported and respondents (55% response rate) might not be representative of the full population. We did not measure training institution or socioeconomic status (which may vary even in this high-earning population, creating unique challenges for some). The sample contained too few single parents to analyze separately. Confounding or reverse causation is possible. However, the findings suggest the possibility that facilitating attendance at national meetings might engage physicians in ways that may improve well-being and professional satisfaction.