自噬
PI3K/AKT/mTOR通路
细胞生物学
安普克
蛋白激酶B
癌症研究
程序性细胞死亡
生物
细胞凋亡
信号转导
蛋白激酶A
磷酸化
生物化学
作者
Yijing Cao,Yichen Luo,Juan Zou,Jingping Ouyang,Zhihong Chen,Xi Zeng,Hui Ling,Tiebing Zeng
标识
DOI:10.1016/j.cca.2018.11.028
摘要
Autophagy, which is tightly regulated by a series of autophagy-related genes (ATGs), is a vital intracellular homeostatic process through which defective proteins and organelles are degraded and recycled under starvation, hypoxia or other specific cellular stress conditions. For both normal cells and tumour cells, autophagy not only sustains cell survival but can also promote cell death. Autophagy-related signalling pathways include mTOR-dependent pathways, such as the AMPK/mTOR and PI3K/Akt/mTOR pathways, and non-mTOR dependent pathways, such as the P53 pathway. Additionally, autophagy plays a dual role in gastric carcinoma (GC), including a tumour-suppressor role and a tumour-promoter role. Long-term Helicobacter pylori infection can impair autophagy, which may eventually promote tumourigenesis of the gastric mucosa. Moreover, Beclin1, LC3 and P62/SQSTM1 are regarded as autophagy-related markers with GC prognostic value. Autophagy inhibitors and autophagy inducers show promise for GC treatment. This review describes research progress regarding autophagy and its significant role in gastric cancer.
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