纳米医学
材料科学
干细胞
碳二亚胺
纳米颗粒
氧化铁纳米粒子
间充质干细胞
纳米技术
生物物理学
化学
高分子化学
病理
医学
细胞生物学
生物
作者
Xinxin Hao,Bei Xu,Huan Chen,Xiaomeng Wang,Jiulong Zhang,Rui Guo,Xiangyang Shi,Xueyan Cao
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2019-01-01
卷期号:11 (11): 4904-4910
被引量:32
摘要
The development of new nanoplatforms with enhanced tumor accumulation for accurate diagnosis still remains a great challenge in current precision nanomedicine. Herein, we report the design of stem cell-mediated delivery of nanogels (NGs) loaded with ultrasmall iron oxide (Fe3O4) nanoparticles (NPs) for enhanced magnetic resonance (MR) imaging of tumors. In this study, sodium citrate-stabilized ultrasmall Fe3O4 NPs with a size of 3.16 ± 1.30 nm were first synthesized using a solvothermal route, coated with polyethyleneimine (PEI), and used as crosslinkers to crosslink alginate (AG) NGs formed via a double emulsion approach, where the AG carboxyl groups were pre-activated with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride. The thus prepared Fe3O4 NP-loaded NGs (AG/PEI-Fe3O4 NGs) with a size of 47.68 ± 3.41 nm are water-dispersible, colloidally stable, cytocompatible in a given concentration range, display a relatively high r1 relaxivity (r1 = 1.5 mM-1 s-1), and are able to be taken up by bone mesenchymal stem cells without compromising cell viability and stem cell characteristics. Due to the tumor-chemotaxis or tumor tropism, the BMSCs are able to mediate the enhanced delivery of AG/PEI-Fe3O4 NGs to the tumor site after intravenous injection, thus enabling significantly strengthened MR imaging of tumors when compared to free NGs. These findings suggest that the developed AG/PEI-Fe3O4NGs, once mediated by stem cells may serve as a novel, safe, effective and targeted platform for enhanced MR imaging of tumors.
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