Advances in biocompatibility of mesoporous silica nanoparticles

Because of the good physical and chemical properties of mesoporous silica nanoparticles( MSNs),MSNs Have broad prospect of application in disease diagnosis and treatment,but before it can be successfully applied in the human body,the biocompatibility of it must be improved. The cytotoxicity of MSNs was related to the way and quantity it can be uptaken into the cells. Those depend on the cell type and character of the MSNs. By improvement of physical and chemical methods,the biocompatibility of mesoporous silica nanoparticles can be obviously improved,and its hemolysis can be reduced too. MSNs distribute mainly in the liver,spleen,lungs,kidney,intestines,stomach,muscle and heart. The toxicity depend on the concentration. As a foreign matter,a certain extent hypersensitivity can be induced when the MSNs enter into the body( in vivo),MSNs exhibit good biocompatibility in vitro and in vivo,but the way to be adopted needs further study.