Quantitative evaluation of hepatic fibrosis and cirrhosis in rats by ultrasonic integrated backscatter

Objective To discuss the quantitative assessment of hepatic fibrosis and cirrhosis of rats induced by CCl_4 using ultrasonic integrated backscatter (IBS) and compare with pathological features. Methods Liver's IBS parameters of normal rats and those of injected CCl_4 were measured by AII and AII%. All data were divided into three groups according to the pathologic standard: control group, hepatic fibrosis group and cirrhosis group. Results AII and AII% of case group were higher than those of control groups (P0.01). AII and AII% of cirrhosis group were higher than those of hepatic fibrosis group (P0.01). Conclusion Ultrasonic IBS can detect hepatic fibrosis early, which is able to quantitatively evaluate hepatic fibrosis and cirrhosis.