Objective:To analyze the effect of Cyclosporine A and prednisone in treatment of nephrotic syndrome.Methods:48 cases of nephrotic syndrome patients were divided into two groups randomly.The treatment group were given cyclosporine A and prednisone,the control group were given prednisone only.Compared the biochemical improvement and efficacy.Results:The control group improved 87.5%,the treatment group was 95.83%,it was significantly different (P 0.05).Conclusion:Cyclosporine A and prednisone in treatment of nephrotic syndrome,the effect is significant and safety,and has little adverse reaction.It is worthy of further using.