Synthesis and wound healing of alternating block polyurethanes based on poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG)

Journal of Biomedical Materials Research Part B: Applied BiomaterialsVolume 105, Issue 5 p. 1200-1209 Original Research Report Synthesis and wound healing of alternating block polyurethanes based on poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG) Linjing Li, Linjing Li Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 ChinaSearch for more papers by this authorXiangyu Liu, Xiangyu Liu Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 ChinaSearch for more papers by this authorYuqing Niu, Yuqing Niu Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 ChinaSearch for more papers by this authorJianfu Ye, Jianfu Ye Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 ChinaSearch for more papers by this authorShuiwen Huang, Shuiwen Huang Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 ChinaSearch for more papers by this authorChao Liu, Chao Liu Aleo BME, Inc, University Park, Pennsylvania, 16802Search for more papers by this authorKaitian Xu, Corresponding Author Kaitian Xu kaitianxu@yahoo.com Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 China Department of Materials Science and Engineering, Jinan University, Guangzhou, 510632 ChinaCorrespondence to: K. Xu; e-mail: kaitianxu@yahoo.comSearch for more papers by this author Linjing Li, Linjing Li Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 ChinaSearch for more papers by this authorXiangyu Liu, Xiangyu Liu Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 ChinaSearch for more papers by this authorYuqing Niu, Yuqing Niu Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 ChinaSearch for more papers by this authorJianfu Ye, Jianfu Ye Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 ChinaSearch for more papers by this authorShuiwen Huang, Shuiwen Huang Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 ChinaSearch for more papers by this authorChao Liu, Chao Liu Aleo BME, Inc, University Park, Pennsylvania, 16802Search for more papers by this authorKaitian Xu, Corresponding Author Kaitian Xu kaitianxu@yahoo.com Multidisciplinary Research Center, Shantou University, Shantou, Guangdong, 515063 China Department of Materials Science and Engineering, Jinan University, Guangzhou, 510632 ChinaCorrespondence to: K. Xu; e-mail: kaitianxu@yahoo.comSearch for more papers by this author First published: 05 April 2016 https://doi.org/10.1002/jbm.b.33670Citations: 20Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Alternating block polyurethanes (abbreviated as PULA-alt-PEG) and random block polyurethanes (abbreviated as PULA-ran-PEG) based on biodegradable poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG) were prepared. Results showed that alternating block polyurethane gives higher crystal degree, higher mechanical properties, more patterned and rougher surface than the random counterpart, due to the regular and controlled structure. Water absorptions of the polyurethanes were in the range of 620 to 780%. Cytocompatibility of the amphiphilic block polyurethanes (PU) (water static angle 41.4°–61.8°) was assessed by CCK-8 assay using human embryonic kidney (HEK293) cells. Wound healing evaluation of the PU foam scaffolds was carried out by full-thickness SD rat model experiment, with medical gauze as control. It was found that the skin of rat in PU groups was fully covered with new epithelium without any significant adverse reactions and PU dressings give much rapid and better healing than medical gauze. Histological examination revealed that PU dressings suppress the infiltration of inflammatory cells and accelerate fibroblast proliferation. It was also demonstrated that PULA-alt-PEG exhibits obvious better healing effect than PULA-ran-PEG does. This study has demonstrated that without further modification, plain alternating block polyurethane scaffold would help wound recovery efficiently. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1200–1209, 2017. Citing Literature Supporting Information Additional Supporting Information may be found in the online version of this article. Filename Description jbmb33670-sup-0001-suppinfo.docx19 MB Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume105, Issue5July 2017Pages 1200-1209 RelatedInformation