The authors have studied on safety for combined laser therapy (C. L. T.). The method of C. L. T. is to combine some kinds of lasers together taking advantage of each different effect on human body in order to achieve more effective treatment. For the laser safety in the C. L. T. method, the unique safety systems should be required as follows;1. The difference of the optical characteristics of the tissues to each laser must be considered.2. Laser protective eyewear must simultaneously cut off the lasers of every wavelengths perfectly.3. The tissues located in surrounding area of the target should be protected against accidental radiation of every lasers using in the C. L. T..4. In using some kinds of lasers together, a hand-switch should be provided for each laser handpiece to avoid mis-shot.5. Every laser can be distinguished easily by the each light guide.6. The white light is applicable for every guide light in the C. L. T..