Short-term and Medium-term Clinical Effect of Liver Dispersing with Spleen Strengthening on Irritable Bowel Syndrome Dominated by Diarrhea

Objective To observe the short-term and medium-term clinical effect of the therapy of liver dispersing with spleen strengthening on irritable bowel syndrome dominated by diarrhea(IBS-D). Methods One hundred and seven patients with IBS-D were divided randomly into 2 groups, 53 of them were treated with the decoction of liver dispersing with spleen strengthening(herb group), and the other 54 were treated with Pinaverium Bromide(Pinaverium Bromide group). The course of treatment was 4 weeks, and there was a 3-month follow-up. The scores of symptoms and IBS-quality of life(QOL) were recorded twice in every 2 weeks, and 1st and 3rd month after treatment. Results 1) After the 4 weeks treatment, the total effective rate on symptoms of the herb group was 90.6%,while the Pinaverium Bromide group was 70.4%(P0.05). Also, the former had better effect on the frequency of defecation and characters of stool(P0.05). 2) As the improvement in the scores of symptom, the herb group had better effect than Pinaverium Bromide group(P0.05) at the 1st and 3rd month follow-ups. 3) According to IBS-QOL, the herb group significantly improved the patients' quality of life, which was better than Pinaverium Bromide group at the 4th week(P0.05), and the effect sustained to the 3rd month. Conclusion The therapy of liver dispersing with spleen strengthening on IBS-D had predominant effect in short-term and medium-term, and improved the quality of life, which lasted till the 3rd month.