Effect of Shangke Zhitong Plaster on Nitric Oxide and Superoxide Dismutase Level in Rat Model of Acute Soft Tissue Injury

Objective:To observe the effect of Shangke Zhitong Plaster(SKZT) on nitric oxid(NO) and superoxide dismutase(SOD) level of the located soft tissue in rat model of acute soft tissue injury.Method:Model of acute soft tissue injury in rats was made,then they were divided into groups and given with drugs.Such dynamic items as index numbers of injury symptoms,parameters of histological anatomy and morphometry were investigated,and changes of NO and SOD in soft tissue were determined.Result:SKZT Plaster had favorable improvement on rat models of acute soft tissue injury,drug group was super to control group on index numbers of injury symptoms and histological anatomy recovery.SKZT Plaster could significantly decrease the elevation of NO in injured soft tissue and increase the contents of SOD in injured soft tissue in a dose-dependent way.Conclusion: SKZT Plaster could increase the level of SOD and inhibit the elevation of NO in injured soft tissue,this may be one of the mechanisms that SKZT Plaster can be used to treat acute soft tissue injury.