生物膜
微生物学
最低杀菌浓度
生物
细菌
最小抑制浓度
铜绿假单胞菌
金黄色葡萄球菌
毒性
大肠杆菌
金属毒性
抗生素
化学
生物化学
遗传学
有机化学
基因
作者
Joe J. Harrison,Howard Ceri,Carol A. Stremick,Raymond J. Turner
标识
DOI:10.1111/j.1462-2920.2004.00656.x
摘要
Summary This study compared bacterial biofilm and planktonic cell susceptibility to metal toxicity by evaluating the minimum inhibitory concentration (MIC), the planktonic minimum bactericidal concentration (MBC), and minimum biofilm eradication concentration (MBEC) using the MBEC™ device. In total, 17 metal cations and oxyanions, chosen to represent groups VIB to VIA of the periodic table, were each tested on biofilm and planktonic cultures of Escherichia coli JM109, Staphylococcus aureus ATCC 29213, and Pseudomonas aeruginosa ATCC 27853. In contrast to control antibiotic assays, where biofilm cultures were 2 to 64 times less susceptible to killing than logarithmically growing planktonic bacteria, metal compounds killed planktonic and biofilm cultures at the same concentration in the vast majority of combinations. Our data indicate that, under the conditions reported, growth in a biofilm does not provide resistance to bacteria against killing by metal cations or oxyanions.
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