基因型
优势比
医学
致癌物
风险因素
病例对照研究
癌症
遗传倾向
生理学
人口
内科学
遗传学
肿瘤科
基因
生物
胃肠病学
环境卫生
作者
Miki Sato,Takayuki Sato,Toshiyuki Izumo,Teruo Amagasa
出处
期刊:Carcinogenesis
[Oxford University Press]
日期:1999-10-01
卷期号:20 (10): 1927-1931
被引量:128
标识
DOI:10.1093/carcin/20.10.1927
摘要
An individual difference in the susceptibility to chemical carcinogens is one of the most important factors in the estimate of risk of human cancer. Recently, it has been reported that genetic risk for tobacco-related cancers is associated with polymorphisms of the CYP1A1 and GSTM1 genes in terms of genotype frequencies and cigarette smoking dose. In this study, we investigated the inter-individual difference in genetically determined susceptibility to oral squamous cell carcinoma (SCC) in relation to cigarette smoking dose in a Japanese population. DNA samples were obtained from both patients and controls. We identified individuals at high risk genetically for oral SCC in terms of polymorphisms of the CYP1A1 and GSTM1 genes. This study then compared the estimated total number of cigarettes smoked by patients with those smoked by controls. In this case–control study, we estimated the odds ratios of susceptible to non-susceptible individuals. CYP1A1 genotype C and GSTM1 deficiency were frequently found among oral SCC patients. Patients with genotype C and GSTM1 deficiency contracted carcinoma after fewer cigarettes than those with other genotypes. Individuals with these two genotypes were at remarkably high risk at a low dose level of cigarette smoking. Individual differences in polymorphisms of the CYP1A1 and GSTM1 genes is one important factor in the estimate of risk of oral SCC at a low dose level of cigarette smoking.
科研通智能强力驱动
Strongly Powered by AbleSci AI